Example:-
A. Flurbiprofen sodium
B. Diclofenac sodium
C. Ketorolac tromethamine
D. Indomethacin
E. Bromfenac
F. Nepafenac
G. Ibuprofen
H. Mefenamic acid
I. Aceclofenac
J. Nimesulide
K. Aspirin
L. Celecoxib
M. Etoricoxib
USE:-
1. As prophylactic & therapeutic agents in CME (cystoid macular edema).
2. Reduced ocular inflammation when steroid are contraindicated; as in vernal conjunctivitis, scleritis, allergic conjunctivitis, mild iridocyclitis & post-operative pain in the eyes.
3. Post-operative eye pain
4. Menstrual pain
5. Myalgia/ neuralgia
6. Headache/ backache
7. Fever
8. Osteoarthritis
9. Rheumatoid arthritis.
NSAIDS INTERACTION:-
1. SULFONYLUREAS- ( liver & kidney damage)
Phenytoin
Methotrexate
Valporate
2. Warfarin:- Heparin
3. ACE inhibitors:- thiazide, diuretic
4. Beta blockers:- fruosemide
Increase risk of gastric mucosal damage & gastric bleeding.
CONTRAINDICATION:-
- NSAIDs hypersensitivity or salicylate hypersensitivity.
- Allergic reaction after taking NSAIDs
- Who have undergone coronary artery bypass graft surgery.
- Person with peptic ulcers and stomach bleeding.
- Liver toxicity or long term use.
- During pregnancy & breast feeding mother
SIDE EFFECTS:-
- Indigestion
- Stomach ulcers
- Headache
- Dizziness
- Allergic reaction
- Feeling sick
- Diarrhea
NSAIDS have 3 properties
A. Analgesic
B. Antipyretics
C. Anti-inflammatory
TYPES:-
1. NON-SELECTIVE COX II INHIBITORS ( high side effects):-
- Aspirin (salicylate)
- Ketoprofen
- Ketorolac
- Mefenamic acid
- Ibuprofen
- Piroxicam
2. SEMI-SELECTIVE (COX-II) :-
- Diclofenac
- Nimesulide
- Aceclofenac
3. SELECTIVE COX-II INHIBITORS:-
- Celecoxib
- Etoricoxib
- Parecoxib
4. POOR ANTI-INFLAMMATORY:-
- Paracetamol
In ocular pharmacology we use following NSAIDS drops:-
- Flurbiprofen
- Ketorolac
- Bromfenac
- Nepafenac
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FLURBIPROFEN
It is a pain relieving medicine,it is used for treatment of post-operative eye pain & inflammation.
Helps relieve symptoms after an eye surgery such as pain, redness, itching, soreness or watery eyes.
Mainly use after cataract surgery.
SIDE EFFECTS:-
- Eye discomfort
- Blurred vision
- Burning sensation
- Tearing
MECHANISM OF ACTION:-
👉It is a NSAIDs drug, it works by blocking the release of certain chemical messengers that cause fever, pain, inflammation ( redness & swelling).
USES:- it is effective in relieving pain & inflammation. It is used to provide relief from various sorts of pain, such as sprains, strains & other injuries. It is also helpful in the treatment of different types of arthritis & gout.
BRAND NAME -COMPANY NAME - COMPOSITION::-
👉OCUFLUR (FDC LTD.) :- Flurbiprofen 0.03% w/v
👉FBN ( MICROLABS LTD) :- Flurbiprofen 0.03% w/v
👉FLUR ( ALLERGAN INDIA PVT):@ Flurbiprofen (0.03%w/v) + HPMC (0.25% w/v) + phenyl mercuric nitrate (0.002% w/v )
👉Flurbin ( optho pharma) :- Flurbiprofen (0.03%) + HPMC (0.25% w/v)
KETOROLAC TROMETHAMINE
It is a pain relieving medicine,it is used for treatment of post-operative eye pain & inflammation.
Helps relieve symptoms after an eye surgery such as pain, redness, itching, soreness or watery eyes.
Mainly use after cataract surgery.
SIDE EFFECTS:-
Eye discomfort
Blurred vision
Burning sensation
Tearing
MECHANISM OF ACTION:-
👉It is a NSAIDs drug, it works by blocking the release of certain chemical messengers that cause fever, pain, inflammation ( redness & swelling).
USES:- it is effective in relieving pain & inflammation. It is used to provide relief from various sorts of pain, such as sprains, strains & other injuries. It is also helpful in the treatment of different types of arthritis & gout.
⭕SAME AS FLURBIPROFEN, IT IS AVAILABLE WITH COMBINATION DRUG.
⭕BEST FOR ANTERIOR SEGMENT- )BOTH FLURBIPROFEN & KETOROLAC TROMETHAMINE.
NAME OF THE BRAND AVAILABLE:-
⭐ MOXIFLOXACIN+ KETOROLAC TROMETHAMINE:-
- Apdrops-kt
- Moxicip-kt
- Vigoquin-kt
- Moxigram-kt
- Moximax-kt
- Milflox plus
- Mahaflox-kt
⭐ ANTIHISTAMINIC+ KETOROLAC TROMETHAMINE:-
1. OLOPAT- KT
2. ALCAREX-KT
NEPAFENAC (0.1%)
It is a pain relieving medicine,it is used for treatment of post-operative eye pain & inflammation.
Helps relieve symptoms after an eye surgery such as pain, redness, itching, soreness or watery eyes.
Mainly use after cataract surgery.
SIDE EFFECTS:-
- Eye discomfort
- Blurred vision
- Burning sensation
- Tearing
MECHANISM OF ACTION:-
👉It is a NSAIDs drug, it works by blocking the release of certain chemical messengers that cause fever, pain, inflammation ( redness & swelling).
USES:- it is effective in relieving pain & inflammation. It is used to provide relief from various sorts of pain, such as sprains, strains & other injuries. It is also helpful in the treatment of different types of arthritis & gout.
⭐Best use in posterior segment disease - retinal & vitreous problems.
BRAND NAME:
- Nepalact- z - sun pharma
- Nepaflam - Ajanta pharma
- Nepastar- mankind pharma
- Nepcinac - Cipla
- Oxiflam - ipca laboratories
- Nepaflam-ODB- AJANTA PHARMA
- NEPALACT- SUN PHARMA
- NEPAVON -CS :- NEOMEDIX
BROMFENAC
It is a pain relieving medicine,it is used for treatment of post-operative eye pain & inflammation.
Helps relieve symptoms after an eye surgery such as pain, redness, itching, soreness or watery eyes.
Mainly use after cataract surgery.
SIDE EFFECTS:-
- Eye discomfort
- Blurred vision
- Burning sensation
- Tearing
MECHANISM OF ACTION:-
👉It is a NSAIDs drug, it works by blocking the release of certain chemical messengers that cause fever, pain, inflammation ( redness & swelling).
USES:- it is effective in relieving pain & inflammation. It is used to provide relief from various sorts of pain, such as sprains, strains & other injuries. It is also helpful in the treatment of different types of arthritis & gout.
MEGABROM( BROMFENAC 0.09% w/v) :- SUN PHARMA
BROMVUE( BROMFENAC 0.09%) :- IPCA LABORATORIES
UNIBROM( BROMFENAC 0.09%):- AJANTA PHARMA
DUOBROM( BROMFENAC 0.09% + MOXIFLOXACIN 0.5%):- AJANTA PHARMA
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THANK YOU
RAIN HEALTH CARE
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